Upon its release, The Female Boss has received generally negative reviews from most music critics, with many critics panning the themes, intro of the album, production and some lyrical content, while some critics felt the dance songs were highlights. Commercially, the album opened with poor sales, debuting at number 35 on the UK Albums Chart and number 55 in Ireland.
Mitochondrial antiviral-signaling protein (MAVS) is a protein that in humans is encoded by the MAVSgene. The protein is also known by the names VISA (virus-induced signaling adapter), IPS-1 and Cardif. Aggregated MAVS forms protease resistant prion-like aggregates that activate IRF3 dimerization.
Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 or by the cytoplasmic RNA helicases MDA5 and RIGI. These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK) and IKKB (IKBKB; MIM 603258), which activate NFKB, or TBK1 and IKBKE (IKBKE), which activate IRF3. Activated IRF3 and NFKB induce transcription of IFNβ (IFNB1). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1). For RIGI, the intermediary protein is mitochondria-bound MAVS.
The island has been inhabited since the 17th century, when people from Europe (mostly France), Madagascar and Africa settled there. Slavery was abolished on 20 December 1848 (a date celebrated yearly on the island), after which indentured workers were brought from South India, among other places. The island became an overseas department of France in 1946.
The local language, spoken by the majority of the population, is Réunion Creole. The official language is French.
In the episode, K'Ehleyr returns to the Enterprise to advise Captain Picard, who is chosen to arbitrate the selection of the new Klingon leader from two candidates, Gowron and Duras, one of whom is suspected to be a traitor.
The starshipEnterprise is met by a KlingonVor'cha class battlecruiser, and Ambassador K'Ehleyr (Suzie Plakson) requests to speak to Captain Picard (Patrick Stewart) on an "urgent matter". When she beams aboard, she brings a young Klingon boy (Jon Paul Steuer); based on his previous romantic experience with K'Ehleyr, Lt. Worf (Michael Dorn) suspects the child is his son. K'Ehleyr warns the senior staff of a power struggle occurring within the Klingon Empire and implores Picard to meet Chancellor K'mpec (Charles Cooper) aboard the battlecruiser. On the Klingon ship, K'mpec acknowledges that he has been poisoned and is slowly dying, and insists that Picard become the Arbiter of Succession and identify his assassin. K'mpec dies shortly afterward. In a private moment, K'Ehleyr confirms to Worf that the Klingon boy is his son, Alexander, and she did not tell Worf for fear he would try to have a deeper relationship with her; Worf, already burdened by his discommendation, fears for Alexander's future, given the stigma of his family name.
Reunion, also known as Merit's Galactic Reunion, is a space strategy video game. It was the Hungarian game developer company Amnesty Design's (now Digital Reality) first game. The game was programmed by János Kistamás, Krisztián Jámbor, and Attila Lendvai (Amiga), István Kiss (DOS). The soundtrack was made by Tamás Kreiner which was the basis of his reputation.
In the 27th century, centuries of peace have allowed great scientific progress in the development of the first interstellar warp drive. Two research ships, designated Explorer-1 and Explorer-2, are outfitted with the experimental drives and sent to find new planets of colonization. Only Explorer-2 returns to Earth out of the two Explorers. Refitted as a colony vessel, the Explorer-2 is once again ready to embark when, suddenly, peace is disrupted and the humans were ripped apart from each other. At this same time, a planet-wide rebellion stages a great coup and overthrows the Earthen government, throwing the world into chaos and severing the union. The Explorer-2, crewed by a loyalist space crew, barely escapes the rebellion and leaves the Solar System. Years later after the rebellion, the Explorer-2 arrives damaged at its destination and a colony is set up, naming it "New Earth". After many generations of being separated from Earth, the colony is self-sufficient enough to develop a mission only the best can tread: Explore nearby space, research new technologies, harvest resources, develop a space fleet and eventually... reconquer and reunify Earth, leading to the greatest reunion the universe has ever set its eyes on.